Abstract
Pitavastatin (CAS 147526-32-7, NK-104), the first totally synthetic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor discovered in Japan, was examined. Pitavastatin significantly decreased the serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) at doses of 1 mg/day or more, and significant dose-dependence of the effect of this drug was observed within the dose range from 1 mg/day to 4 mg/day. It also significantly decreased the serum levels of triglycerides (TG) within this dose range. There was no dose-dependence of the incidence of adverse reactions to pitavastatin.
Publication types
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Clinical Trial
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Cholesterol / blood
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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Dose-Response Relationship, Drug
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Double-Blind Method
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Female
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacokinetics
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
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Hyperlipidemias / blood
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Hyperlipidemias / drug therapy*
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Lipids / blood
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Liver Function Tests
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Male
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Middle Aged
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Quinolines / adverse effects
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Quinolines / pharmacokinetics
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Quinolines / therapeutic use*
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Triglycerides / blood
Substances
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Cholesterol, HDL
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Cholesterol, LDL
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Lipids
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Quinolines
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Triglycerides
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Cholesterol
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pitavastatin