Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections

Sandra M Tallent; Tammy Bischoff; Michael Climo; Belinda Ostrowsky; Richard P Wenzel; Michael B Edmond

doi:10.1128/JCM.40.6.2249-2250.2002

Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections

J Clin Microbiol. 2002 Jun;40(6):2249-50. doi: 10.1128/JCM.40.6.2249-2250.2002.

Authors

Sandra M Tallent¹, Tammy Bischoff, Michael Climo, Belinda Ostrowsky, Richard P Wenzel, Michael B Edmond

Affiliation

¹ Department of Internal Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298, USA. smtallen@hsc.vcu.edu

Abstract

Nosocomial oxacillin-resistant Staphylococcus aureus (ORSA) bloodstream isolates were tested to determine the prevalence of vancomycin heteroresistance. We screened 619 ORSA nosocomial bloodstream isolates from 36 hospitals between 1997 and 2000. Only one isolate exhibiting heterotypic resistance was detected. Thus, vancomycin heteroresistance in clinical bloodstream isolates remains rare in the United States.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacteremia / epidemiology*
Bacteremia / microbiology
Cross Infection / epidemiology*
Cross Infection / microbiology
Drug Resistance, Bacterial*
Hospitalization
Humans
Microbial Sensitivity Tests
Oxacillin / pharmacology
Penicillins / pharmacology
Population Surveillance
Staphylococcal Infections / epidemiology
Staphylococcal Infections / microbiology
Staphylococcus aureus / drug effects*
United States / epidemiology
Vancomycin / pharmacology*

Substances

Anti-Bacterial Agents
Penicillins
Vancomycin
Oxacillin