Oral FK 506 blood levels are elevated in pig short bowel model: further investigations with co-administration of an intestinal CYP3A4 inhibitor

Transplant Proc. 2002 May;34(3):1050-1. doi: 10.1016/s0041-1345(02)02708-2.
No abstract available

MeSH terms

  • Administration, Oral
  • Anastomosis, Surgical
  • Animals
  • Area Under Curve
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors*
  • Disease Models, Animal
  • Enzyme Inhibitors / pharmacology*
  • Ileum / surgery
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / blood
  • Immunosuppressive Agents / pharmacology
  • Intestinal Absorption
  • Intestinal Mucosa / enzymology
  • Jejunum / surgery
  • Ketoconazole / administration & dosage
  • Ketoconazole / blood
  • Ketoconazole / pharmacology*
  • Metabolic Clearance Rate
  • Mixed Function Oxygenases / antagonists & inhibitors*
  • Short Bowel Syndrome / enzymology
  • Short Bowel Syndrome / immunology
  • Short Bowel Syndrome / physiopathology*
  • Short Bowel Syndrome / surgery*
  • Swine
  • Tacrolimus / administration & dosage
  • Tacrolimus / blood*
  • Tacrolimus / pharmacology

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Immunosuppressive Agents
  • Mixed Function Oxygenases
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Ketoconazole
  • Tacrolimus