Abstract
Investigation of a Philippine specimen of the red alga Ceratodictyon spongiosum and its sponge symbiont Haliclona cymaeformis led to the isolation of p-sulfooxyphenylpyruvic acid, whose structure was elucidated using spectroscopic methods, with the Z-enol geometry determined through analysis of (3)J(C,H) coupling constants. The metabolite was tested for tyrosine kinase inhibition using a (3)H-thymidine incorporation assay, but was found inactive.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Carcinoma, Squamous Cell / enzymology
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Carcinoma, Squamous Cell / metabolism
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Cephamycins / pharmacology
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Chromatography / methods
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Dapsone / analogs & derivatives*
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Dapsone / chemistry*
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Dapsone / isolation & purification
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Dapsone / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Phenylpyruvic Acids / chemistry*
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Phenylpyruvic Acids / isolation & purification
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Phenylpyruvic Acids / metabolism
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Phenylpyruvic Acids / pharmacology
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Philippines
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Porifera / chemistry*
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Rhodophyta / chemistry*
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Rhodophyta / metabolism
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Spectrometry, Mass, Electrospray Ionization
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Cephamycins
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Enzyme Inhibitors
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Phenylpyruvic Acids
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sulfooxyphenylpyruvic acid
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sulfoxone
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Dapsone
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Protein-Tyrosine Kinases
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phenylpyruvic acid