Glycosidation of alkylamino-alkan-1-ol. A simple and convenient synthesis of glycosylated cationic lipids

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1447-50. doi: 10.1016/s0960-894x(02)00200-7.

Abstract

Starting from long chain alkylamino-alkan-1-ol a series of amino glycolipids were synthesized. This procedure allows a short and convenient preparation of glycosylated cationic lipids for gene delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations / chemical synthesis
  • Cations / chemistry
  • Glycolipids / chemical synthesis*
  • Glycolipids / chemistry
  • Glycosides / chemistry*
  • Glycosylation
  • Lipids / chemistry
  • Polyamines / chemistry
  • Structure-Activity Relationship

Substances

  • Cations
  • Glycolipids
  • Glycosides
  • Lipids
  • Polyamines