Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in a neutropenic patient

Scand J Infect Dis. 2002;34(3):227-9. doi: 10.1080/00365540110077137.

Abstract

Aspergillus flavus causes invasive external otitis associated with severe infection of the skull base. A combination of amphotericin B, surgical debridement and long-term itraconazole is considered the therapy of choice. We report a case of invasive external otitis due to A. flavus that was treated successfully with a short course of amphotericin B and long-term oral itraconazole without surgical intervention.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Aspergillus flavus / isolation & purification*
  • Child
  • Humans
  • Immunocompromised Host
  • Itraconazole / administration & dosage
  • Itraconazole / therapeutic use*
  • Male
  • Mycoses / complications
  • Mycoses / drug therapy*
  • Mycoses / microbiology*
  • Neutropenia / complications*
  • Neutropenia / microbiology
  • Otitis Externa / complications
  • Otitis Externa / drug therapy*
  • Otitis Externa / microbiology*

Substances

  • Antifungal Agents
  • Itraconazole