Abstract
Using the inhibition of Cu(2+)-induced low-density-lipoprotein (LDL) peroxidation to direct fractionation, four new benzenoids, tournefolal (1), tournefolic acids A (2) and B (3), and B ethyl ester (4), together with salvianolic acid A (5), isosalvianolic acid C (6), lithospermic acid (7), salvianolic acid F (8), and rosmarinic acid (9), were isolated from the stems of Tournefortia sarmentosa. The structures of the new compounds 1-4 were elucidated on the basis of spectral and chemical methods. Furthermore, the anti-LDL-peroxidative activity of the isolated compounds was determined. All isolated compounds exhibited more potent activity than probucol except for salvianolic acid F (8).
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antioxidants / chemistry
-
Antioxidants / isolation & purification*
-
Antioxidants / pharmacology
-
Benzene Derivatives / chemistry
-
Benzene Derivatives / isolation & purification*
-
Benzene Derivatives / pharmacology
-
Boraginaceae / chemistry*
-
Chromatography, Thin Layer
-
Copper / pharmacology
-
Hypolipidemic Agents / chemistry
-
Hypolipidemic Agents / isolation & purification*
-
Hypolipidemic Agents / pharmacology
-
Inhibitory Concentration 50
-
Lipid Peroxidation / drug effects
-
Lipoproteins, LDL / metabolism*
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Oxidation-Reduction
-
Peroxides / metabolism
-
Plant Stems / chemistry
-
Plants, Medicinal / chemistry*
-
Taiwan
Substances
-
Antioxidants
-
Benzene Derivatives
-
Hypolipidemic Agents
-
Lipoproteins, LDL
-
Peroxides
-
Copper