Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil

Antimicrob Agents Chemother. 2002 Jun;46(6):2021-3. doi: 10.1128/AAC.46.6.2021-2023.2002.

Abstract

Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Antigens, Bacterial*
  • Bacterial Proteins / metabolism
  • Brazil / epidemiology
  • Clarithromycin / therapeutic use*
  • DNA, Bacterial / genetics
  • Drug Resistance, Microbial
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / epidemiology*
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / genetics
  • Humans
  • Metronidazole / therapeutic use*
  • Point Mutation

Substances

  • Anti-Bacterial Agents
  • Antigens, Bacterial
  • Bacterial Proteins
  • DNA, Bacterial
  • cagA protein, Helicobacter pylori
  • Metronidazole
  • Clarithromycin