Abstract
Five different morphological types of Maytenus ilicifolia of the same age and harvested under the same conditions showed distinct accumulations of some friedo-nor-oleananes. A rapid, sensitive and reliable reverse-phase HPLC method (employing an external standard) was used for the determination of the cytotoxic triterpenoids, 20 alpha-hydroxymaytenin, 22 beta-hydroxymaytenin, maytenin, celastrol and pristimerin in each of the five types. Well resolved peaks with good detection response and linearity in the range 1.0-100 micrograms/mL were obtained.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Brazil
-
Chromatography, High Pressure Liquid / methods*
-
Maytenus / anatomy & histology
-
Maytenus / chemistry*
-
Maytenus / classification
-
Molecular Structure
-
Oleanolic Acid / analogs & derivatives
-
Plant Bark / chemistry
-
Plant Leaves / chemistry
-
Plant Roots / chemistry
-
Reference Standards
-
Sensitivity and Specificity
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification*
Substances
-
Antineoplastic Agents, Phytogenic
-
Triterpenes
-
oleanane
-
Oleanolic Acid