Tendency of coronary mortality to occur about 10 years later in women than in men is a well known fact. This difference has been attributed to the presence of estrogens in women. Despite the performance of many experimental and observational studies on the heart-protecting effect of estrogens, there are a lot of methodological limitations which make it difficult to obtain definitive results. This revision, shows the experimental studies where it has been demonstrated that estrogens do not increase cardiovascular protection. Emphasis is focused on adverse effects, such as the development of breast and endometrial cancer. It is also emphasized that during menopause, a series of life style modifications can be implemented, such as exercising, stop smoking and loosing weight. Undoubtedly, the results will be cardiovascular health benefits, with minimum integral health risks.