Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II

Phytochemistry. 2002 May;60(2):175-7. doi: 10.1016/s0031-9422(02)00081-x.

Abstract

Crude MeOH extracts from the stem bark and leaves of a Panamanian specimen of Albizia adinocephala (Leguminosae) were found to inhibit the malarial enzyme plasmepsin II. Bioassay guided fractionation led to the isolation of two new bioactive spermine alkaloids, budmunchiamines L4 and L5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / pharmacology*
  • Animals
  • Antimalarials / chemistry
  • Antimalarials / pharmacology
  • Aspartic Acid Endopeptidases / drug effects*
  • Chromatography, High Pressure Liquid
  • Fabaceae / chemistry*
  • Molecular Structure
  • Plant Structures / chemistry
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / enzymology*
  • Protozoan Proteins
  • Spectrophotometry, Infrared
  • Spermine / analogs & derivatives*
  • Spermine / chemistry
  • Spermine / pharmacology*
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Antimalarials
  • Protozoan Proteins
  • Spermine
  • Aspartic Acid Endopeptidases
  • plasmepsin II