Simultaneously monitoring both T(1) and T(2)* signal intensities on a bolus injection of Gd-DTPA may distinguish infarcted myocardium

J Magn Reson Imaging. 2002 May;15(5):532-40. doi: 10.1002/jmri.10104.

Abstract

Purpose: To determine whether injured myocardium may be identified by simultaneously monitoring contrast-induced T(1) and T(2)* signal intensity time-course changes with an interleaved T(1)-T(2)* imaging sequence.

Materials and methods: Gadolinium-diethylene triamine pentaacetic acid (0.05 mmol/ kg) was injected as a bolus into ex vivo pig hearts, and simultaneous T(1) and T(2)* time-courses were obtained during the first pass.

Results: Observing contrast-enhanced R(1) or R(2)* rates (1/T(1) or 1/T(2)* times, respectively) early after contrast injection did not fully differentiate viable from nonviable myocardium. T(2)* recovery at maximal T(1) signal intensity, measured using simultaneous T(1) and T(2)* imaging, displayed a significantly different percentage recovery (P < 0.05) among normal (30.5 +/- 2.4% of baseline value), reperfused infarcted (63 +/- 7.2%), and low-reflow infarcted (90 +/- 2.8%) myocardium.

Conclusion: Simultaneously monitoring both T(1) and T(2)* signal intensities may help in the assessment of myocardial injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Contrast Media / administration & dosage
  • Diagnosis, Differential
  • Disease Models, Animal
  • Gadolinium DTPA* / administration & dosage
  • Injections, Intravenous
  • Microspheres
  • Myocardial Infarction / diagnosis*
  • Regional Blood Flow
  • Swine

Substances

  • Contrast Media
  • Gadolinium DTPA