Intrathecal pethidine as sole anaesthetic agent for operative procedures of the lower limb, inguinal area and perineum

West Indian Med J. 2001 Dec;50(4):313-6.

Abstract

Intrathecal pethidine as a sole anaesthetic agent for surgical procedures of the lower limbs, perineum and inguinal areas was investigated and compared with hyperbaric Bupivacaine. A total of 90 patients were studied and randomly divided into groups 1 (bupivacaine) and 2 (pethidine). In group 2, 26 of 46 patients (59%) had their procedures successfully with intrathecal pethidine alone and did not require or request any additional sedation or analgesia. This compared to 24 of 44 patients (52.2%) in the bupivacaine group. Pethidine had a prolonged postoperative analgesia and was more cost-effective. The incidences of side effects were acceptable. (hypotension 13.6%, bradycardia 9.09%, nausea and vomiting 11.4%, and pruritus 15.9%). Pethidine can be used as a sole anaesthetic agent for operative procedures of the lower limbs; side effects are mild and can be treated.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Ambulatory Surgical Procedures
  • Analgesics, Opioid / administration & dosage*
  • Analgesics, Opioid / adverse effects
  • Anesthesia, Spinal
  • Anesthetics, Local / administration & dosage
  • Bradycardia / etiology
  • Bupivacaine / administration & dosage
  • Double-Blind Method
  • Female
  • Groin / surgery
  • Humans
  • Hypotension / etiology
  • Leg / surgery
  • Male
  • Meperidine / administration & dosage*
  • Meperidine / adverse effects
  • Middle Aged
  • Nausea / etiology
  • Perineum / surgery
  • Respiratory Insufficiency / etiology

Substances

  • Analgesics, Opioid
  • Anesthetics, Local
  • Meperidine
  • Bupivacaine