New synthesis of L-FMAU from L-arabinose

Nucleosides Nucleotides Nucleic Acids. 2002;21(2):155-63. doi: 10.1081/NCN-120003179.

Abstract

A new synthesis of 2'-deoxy-2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil (13, L-FMAU) was achieved in 10 steps from L-arabinose.

MeSH terms

  • Arabinofuranosyluracil / analogs & derivatives*
  • Arabinofuranosyluracil / chemical synthesis*
  • Arabinose / chemistry*

Substances

  • Arabinofuranosyluracil
  • Arabinose
  • clevudine