Abstract
The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Arachidonate 12-Lipoxygenase / drug effects
-
Arachidonate 12-Lipoxygenase / metabolism
-
Arachidonate 5-Lipoxygenase / metabolism
-
Cyclooxygenase 1
-
Dioxolanes / chemistry
-
Dioxolanes / isolation & purification
-
Dioxolanes / pharmacology*
-
Glycosides / chemistry
-
Glycosides / isolation & purification
-
Glycosides / pharmacology*
-
Isoenzymes / drug effects
-
Isoenzymes / metabolism
-
Lipoxygenase Inhibitors* / pharmacology*
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology*
-
Prostaglandin-Endoperoxide Synthases / drug effects
-
Prostaglandin-Endoperoxide Synthases / metabolism
Substances
-
Dioxolanes
-
Glycosides
-
Isoenzymes
-
Lipoxygenase Inhibitors
-
Plant Extracts
-
tuberculatin
-
diphyllin acetyl apioside
-
Arachidonate 12-Lipoxygenase
-
Arachidonate 5-Lipoxygenase
-
Cyclooxygenase 1
-
Prostaglandin-Endoperoxide Synthases