Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum

Planta Med. 2002 Apr;68(4):359-60. doi: 10.1055/s-2002-26747.

Abstract

The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arachidonate 12-Lipoxygenase / drug effects
  • Arachidonate 12-Lipoxygenase / metabolism
  • Arachidonate 5-Lipoxygenase / metabolism
  • Cyclooxygenase 1
  • Dioxolanes / chemistry
  • Dioxolanes / isolation & purification
  • Dioxolanes / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Isoenzymes / drug effects
  • Isoenzymes / metabolism
  • Lipoxygenase Inhibitors* / pharmacology*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Prostaglandin-Endoperoxide Synthases / drug effects
  • Prostaglandin-Endoperoxide Synthases / metabolism

Substances

  • Dioxolanes
  • Glycosides
  • Isoenzymes
  • Lipoxygenase Inhibitors
  • Plant Extracts
  • tuberculatin
  • diphyllin acetyl apioside
  • Arachidonate 12-Lipoxygenase
  • Arachidonate 5-Lipoxygenase
  • Cyclooxygenase 1
  • Prostaglandin-Endoperoxide Synthases