Opposite effects of olanzapine and haloperidol in rat ultrasonic vocalization test

M Siemiatkowski; P Maciejak; H Sienkiewicz-Jarosz; A I Członkowska; J Szyndler; A Gryczyńska; A Płaźnik

Opposite effects of olanzapine and haloperidol in rat ultrasonic vocalization test

Pol J Pharmacol. 2001 Nov-Dec;53(6):669-73.

Authors

M Siemiatkowski¹, P Maciejak, H Sienkiewicz-Jarosz, A I Członkowska, J Szyndler, A Gryczyńska, A Płaźnik

Affiliation

¹ Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.

PMID: 11985344

Abstract

The opposite effects of the classical antipsychotic, haloperidol, and atypical neuroleptic, olanzapine, in the rat ultrasonic vocalization test of anxiety were observed. The present data are discussed in relation to growing body of evidence of specific brain biochemical changes after pretreatment with different antipsychotics.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antipsychotic Agents / pharmacology*
Anxiety / etiology
Anxiety / psychology
Benzodiazepines
Haloperidol / pharmacology*
Ligands
Male
Motor Activity / drug effects
Olanzapine
Pirenzepine / analogs & derivatives
Pirenzepine / pharmacology*
Rats
Rats, Wistar
Receptors, Dopamine / metabolism
Ultrasonics / adverse effects
Vocalization, Animal / drug effects*

Substances

Antipsychotic Agents
Ligands
Receptors, Dopamine
Benzodiazepines
Pirenzepine
Haloperidol
Olanzapine