Ethyl 6-acetylamino-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-6-carboxylate

Acta Crystallogr C. 2002 May;58(Pt 5):o266-7. doi: 10.1107/s0108270102004687. Epub 2002 Apr 11.

Abstract

The title compound, C(20)H(21)NO(3), is a derivative of Aib (alpha-aminoisobutyric acid) and is cyclized at the C(alpha) position by biphenyl rings. The seven-membered ring possesses C2 symmetry. The C(alpha) cyclization causes the backbone to assume a helical conformation in the crystal structure. The packing of the molecules is stabilized by intermolecular C-H.O, C-H.pi and N-H.O hydrogen bonds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Cycloheptanes / chemical synthesis
  • Cycloheptanes / chemistry*
  • Esters / chemical synthesis
  • Esters / chemistry*
  • Glycine / analogs & derivatives*
  • Glycine / chemical synthesis
  • Glycine / chemistry*
  • Models, Molecular
  • Molecular Conformation

Substances

  • Cycloheptanes
  • Esters
  • ethyl 6-acetylamino-6,7-dihydro-5H-dibenzo(a,c)cycloheptene-6-carboxylate
  • Glycine