Abstract
The T helper lymphocyte is responsible for orchestrating an appropriate immune response to pathogens. To do so, it has evolved into two specialized subsets that direct type 1 and type 2 immunity. Here, we discuss the genetic programs that control lineage commitment of progenitor T helper cells along each of these pathways.
MeSH terms
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Animals
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Cell Differentiation*
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Cell Lineage*
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Cytokines / genetics
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DNA-Binding Proteins / metabolism
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GATA3 Transcription Factor
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Gene Expression Regulation*
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Humans
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NFATC Transcription Factors
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Nuclear Proteins*
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Protein Processing, Post-Translational
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-maf
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STAT6 Transcription Factor
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T-Box Domain Proteins
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T-Lymphocytes / cytology*
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T-Lymphocytes / metabolism*
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Trans-Activators / metabolism
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Transcription Factors / metabolism
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Transcription, Genetic
Substances
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Cytokines
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DNA-Binding Proteins
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GATA3 Transcription Factor
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GATA3 protein, human
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MAF protein, human
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NFATC Transcription Factors
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Nuclear Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-maf
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STAT6 Transcription Factor
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STAT6 protein, human
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T-Box Domain Proteins
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T-box transcription factor TBX21
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Trans-Activators
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Transcription Factors