Abstract
Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.
MeSH terms
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Alternative Splicing / genetics
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Animals
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Caenorhabditis elegans Proteins*
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Carrier Proteins
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Conserved Sequence
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Diacylglycerol Kinase / genetics
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Diacylglycerol Kinase / metabolism
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Diacylglycerol Kinase / physiology*
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Diglycerides / metabolism
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Isoenzymes / physiology
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Phosphatidic Acids / metabolism
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Phosphorylation
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Protein Kinase C / metabolism
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Receptors, Drug / metabolism
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Signal Transduction / physiology*
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Tyrosine / metabolism
Substances
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Caenorhabditis elegans Proteins
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Carrier Proteins
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Diglycerides
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Isoenzymes
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Phosphatidic Acids
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Receptors, Drug
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phorbol ester binding protein
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phorbol ester receptor
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Tyrosine
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Diacylglycerol Kinase
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Protein Kinase C