Abstract
[reaction: see text]. An intramolecular cyclization strategy for effecting a biomimetic synthesis of the core structure of the fungal secondary metabolites phomoidrides A and B is described. The cyclization substrate 20 is prepared in eight steps from dibromide 10. Treatment of 20 with triethylamine in acetonitrile results in a rapid cyclization to give 21 and 22 in good yield.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Catalysis
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Cyclization
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Maleic Anhydrides / chemical synthesis*
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Maleic Anhydrides / chemistry
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Models, Molecular
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Molecular Conformation
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Penicillium / metabolism
Substances
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CP 263114
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Indicators and Reagents
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Maleic Anhydrides