Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline

J Nat Prod. 2002 Apr;65(4):566-9. doi: 10.1021/np010298m.

Abstract

Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19beta-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Apocynaceae / chemistry*
  • Bacillus subtilis / drug effects
  • Cladosporium / drug effects
  • Epidermophyton / drug effects
  • Escherichia coli / drug effects
  • Indole Alkaloids / chemistry*
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology
  • Kenya
  • Mass Spectrometry
  • Microsporum / drug effects
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Plant Leaves / chemistry
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects
  • Trichophyton / drug effects

Substances

  • 7,8-dehydro-19beta-hydroxyschizozygine
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Indole Alkaloids
  • isoschizogaline
  • schizogynine