Abstract
Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19beta-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Apocynaceae / chemistry*
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Bacillus subtilis / drug effects
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Cladosporium / drug effects
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Epidermophyton / drug effects
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Escherichia coli / drug effects
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Indole Alkaloids / chemistry*
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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Kenya
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Mass Spectrometry
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Microsporum / drug effects
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plant Leaves / chemistry
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
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Trichophyton / drug effects
Substances
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7,8-dehydro-19beta-hydroxyschizozygine
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Indole Alkaloids
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isoschizogaline
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schizogynine