Abstract
Expansion and contraction of antigen-specific CD8(+) T cells after infection or vaccination results in stable memory. Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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CD8-Positive T-Lymphocytes / immunology*
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Cytokines / physiology
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Homeostasis
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Humans
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Immunologic Memory
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Infections / immunology*
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Membrane Glycoproteins / physiology
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Perforin
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Pore Forming Cytotoxic Proteins
Substances
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Cytokines
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Membrane Glycoproteins
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Pore Forming Cytotoxic Proteins
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Perforin