Nitric oxide release from coumarin 4-carboxamidoximes in the presence of thiols

Christos A Kontogiorgis; Dimitra J Hadjipavlou-Litina

doi:10.1055/s-0031-1299881

Nitric oxide release from coumarin 4-carboxamidoximes in the presence of thiols

Arzneimittelforschung. 2002;52(3):205-10. doi: 10.1055/s-0031-1299881.

Authors

Christos A Kontogiorgis¹, Dimitra J Hadjipavlou-Litina

Affiliation

¹ Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece.

PMID: 11963649
DOI: 10.1055/s-0031-1299881

Abstract

Coumarin 4-carboxamides with potent anti-inflammatory activity were studied for nitric oxide release in the presence of thiol cofactors in vitro. It was found that NO2- release was dependent on the nature of thiol.

MeSH terms

Coumarins / chemistry*
Cysteine / chemistry
Nitric Oxide / chemistry*
Nitric Oxide Donors / chemistry*
S-Nitroso-N-Acetylpenicillamine / chemistry
Spectrophotometry, Ultraviolet
Sulfhydryl Compounds / chemistry*

Substances

Coumarins
Nitric Oxide Donors
Sulfhydryl Compounds
Nitric Oxide
S-Nitroso-N-Acetylpenicillamine
Cysteine