Chemical synthesis and calcium release activity of N(1)-ether strand substituted cADPR mimic

Bioorg Med Chem Lett. 2002 Mar 25;12(6):887-9. doi: 10.1016/s0960-894x(02)00033-1.

Abstract

8-Chloro cyclic inosine 5'-diphosphate ethoxymethyl ether 3 was synthesized by means of chemical method from protected inosine via phenylthio-type biphosphate substrate. The detection of Ca(2+) release activity shows that 3 is a potent agonist of cADPR and has activity in intact Hela cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism*
  • Cyclic ADP-Ribose / agonists*
  • Cyclic ADP-Ribose / chemistry
  • Ethers / chemical synthesis*
  • Ethers / chemistry
  • Ethers / pharmacology
  • HeLa Cells
  • Humans
  • Molecular Mimicry
  • Structure-Activity Relationship

Substances

  • Ethers
  • Cyclic ADP-Ribose
  • Calcium