Abstract
8-Chloro cyclic inosine 5'-diphosphate ethoxymethyl ether 3 was synthesized by means of chemical method from protected inosine via phenylthio-type biphosphate substrate. The detection of Ca(2+) release activity shows that 3 is a potent agonist of cADPR and has activity in intact Hela cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium / metabolism*
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Cyclic ADP-Ribose / agonists*
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Cyclic ADP-Ribose / chemistry
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Ethers / chemical synthesis*
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Ethers / chemistry
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Ethers / pharmacology
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HeLa Cells
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Humans
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Molecular Mimicry
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Structure-Activity Relationship
Substances
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Ethers
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Cyclic ADP-Ribose
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Calcium