Abstract
Natural killer (NK) cell function is regulated by NK receptors that bind either classical MHC class I (MHC-I) molecules or their structural relatives (MICA, RAE-1 and H-60). Two distinct families of NK receptors have been identified: the C-type lectin-like family (Ly49, NKG2D and CD94/NKG2) and the immunoglobulin-like family (KIRs and LIRs). Here, we describe the crystal structure of the C-type lectin-like NK receptor (Ly49A), bound to its MHC-I ligand (H-2D(d)). We also discuss results from recent mutagenesis studies of the Ly49A/H-2D(d) interaction in the context of the complex structure.
MeSH terms
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Animals
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Antigens, Ly*
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Histocompatibility Antigens Class I / chemistry*
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Histocompatibility Antigens Class I / immunology
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Humans
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Killer Cells, Natural / immunology*
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Lectins, C-Type
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Membrane Glycoproteins / chemistry*
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Membrane Glycoproteins / immunology
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Mice
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Models, Molecular
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NK Cell Lectin-Like Receptor Subfamily A
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Protein Structure, Tertiary
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Receptors, Immunologic / chemistry*
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Receptors, Immunologic / immunology
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Receptors, NK Cell Lectin-Like
Substances
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Antigens, Ly
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Histocompatibility Antigens Class I
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Klra1 protein, mouse
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Lectins, C-Type
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Membrane Glycoproteins
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NK Cell Lectin-Like Receptor Subfamily A
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Receptors, Immunologic
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Receptors, NK Cell Lectin-Like