Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells

Gary Entrican; Sean Wattegedera; Michelle Chui; Lyn Oemar; Mara Rocchi; Colin McInnes

doi:10.1128/IAI.70.5.2690-2693.2002

Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells

Infect Immun. 2002 May;70(5):2690-3. doi: 10.1128/IAI.70.5.2690-2693.2002.

Authors

Gary Entrican¹, Sean Wattegedera, Michelle Chui, Lyn Oemar, Mara Rocchi, Colin McInnes

Affiliation

¹ Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, Scotland, United Kingdom. gary.entrican@mri.sari.ac.uk

Abstract

The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Spontaneous / etiology*
Chlamydophila / drug effects*
Chlamydophila / growth & development
Chlamydophila / pathogenicity
Chlamydophila psittaci
Enzyme Induction / drug effects
Female
HeLa Cells
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
Interferon-gamma / pharmacology*
Pregnancy
Trophoblasts / microbiology*
Tryptophan Oxygenase / biosynthesis*
Tumor Cells, Cultured

Substances

Indoleamine-Pyrrole 2,3,-Dioxygenase
Interferon-gamma
Tryptophan Oxygenase