In a study designed to examine how intimate partners' coping processes with regard to infertility predicted depressive symptoms across the course of a treatment cycle, 43 couples completed assessments in the week prior to and the week after receiving a negative pregnancy result from an alternate insemination attempt by the partner. Depressive symptoms in both partners increased significantly after the pregnancy result receipt. As hypothesized, avoidant coping predicted increased distress over time. and approach-oriented coping (e.g., problem-focused coping, emotional processing, and expression) predicted decreased distress. Coping strategies engaged in by both individuals and partners predicted depressive symptoms, and for women, interactions also emerged between their own and their partners' coping.