Undifferentiated ganglioneuroblastoma in a sheep

J Comp Pathol. 2002 Feb-Apr;126(2-3):216-9. doi: 10.1053/jcpa.2001.0527.

Abstract

Ganglioneuroblastoma, presumably originating from the adrenal medulla, was found in an 18-month-old sheep. Histologically, the tumour was mainly composed of undifferentiated neuroblasts with neuropil and occasional ganglion cells. The morphological and immunohistochemical features with respect to intermediate filament proteins and the neuroendocrine nature of the tumour are described. The neoplastic cells were positive for neuron-specific enolase, synaptophysin and vimentin.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / chemistry
  • Adrenal Gland Neoplasms / pathology
  • Adrenal Gland Neoplasms / veterinary*
  • Adrenal Medulla / chemistry
  • Adrenal Medulla / pathology*
  • Animals
  • Biomarkers, Tumor / analysis
  • Ganglioneuroblastoma / chemistry
  • Ganglioneuroblastoma / secondary
  • Ganglioneuroblastoma / veterinary*
  • Immunoenzyme Techniques / veterinary
  • Phosphopyruvate Hydratase / analysis
  • Sheep
  • Sheep Diseases / pathology*
  • Synaptophysin / analysis
  • Vimentin / analysis

Substances

  • Biomarkers, Tumor
  • Synaptophysin
  • Vimentin
  • Phosphopyruvate Hydratase