Abstract
Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen-activated protein kinases) is discussed and the predictive binding affinities are calculated. Syntheses of original diarylimidazo[2,1-a]phthalazines obtained by Suzuki coupling are described.
MeSH terms
-
Binding Sites
-
Enzyme Inhibitors / chemical synthesis
-
Enzyme Inhibitors / chemistry
-
Humans
-
Imidazoles / chemical synthesis*
-
Imidazoles / chemistry
-
Ligands
-
Mitogen-Activated Protein Kinases / antagonists & inhibitors*
-
Phthalazines / chemical synthesis*
-
Phthalazines / chemistry
-
Protein Binding
-
Structure-Activity Relationship
-
p38 Mitogen-Activated Protein Kinases
Substances
-
Enzyme Inhibitors
-
Imidazoles
-
Ligands
-
Phthalazines
-
Mitogen-Activated Protein Kinases
-
p38 Mitogen-Activated Protein Kinases