Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease

Microbes Infect. 2002 Apr;4(4):449-60. doi: 10.1016/s1286-4579(02)01560-5.

Abstract

Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / immunology
  • Arthritis, Rheumatoid / immunology
  • COP9 Signalosome Complex
  • DNA-Binding Proteins / metabolism
  • Glomerulonephritis / immunology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Lung Diseases / immunology
  • Macrophage Migration-Inhibitory Factors / chemistry
  • Macrophage Migration-Inhibitory Factors / genetics
  • Macrophage Migration-Inhibitory Factors / immunology*
  • Macrophage Migration-Inhibitory Factors / physiology
  • Neoplasms / blood supply
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Peptide Hydrolases
  • Receptors, Immunologic / metabolism
  • Shock, Septic / immunology
  • Signal Transduction
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Macrophage Migration-Inhibitory Factors
  • Receptors, Immunologic
  • Transcription Factors
  • macrophage migration inhibitory factor receptor
  • Peptide Hydrolases
  • COPS5 protein, human
  • COP9 Signalosome Complex