Abstract
Diclofenac is a potent anti-inflammatory and analgesic compound with good antipyretic and uricosuric properties. It is one of the most potent inhibitors of prostaglandin synthetase known. It shows a favourable therapeutic ratio considering its efficacy, and proved superior to the reference drugs in terms of gastro-intestinal tolerability. All metabolites are clearly less potent than the parent compound.
MeSH terms
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Analgesics
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Animals
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Arthritis, Experimental / drug therapy
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Cyclooxygenase Inhibitors
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Diclofenac / adverse effects
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Diclofenac / metabolism
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Diclofenac / pharmacology*
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Dose-Response Relationship, Drug
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Drug Tolerance
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Humans
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Mice
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Models, Biological
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Phenylacetates / pharmacology*
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Rats
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Uricosuric Agents
Substances
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Analgesics
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Phenylacetates
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Uricosuric Agents
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Diclofenac