Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): Structures of myrciacitrins III, IV, and V

Hisashi Matsuda; Norihisa Nishida; Masayuki Yoshikawa

doi:10.1248/cpb.50.429

Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): Structures of myrciacitrins III, IV, and V

Chem Pharm Bull (Tokyo). 2002 Mar;50(3):429-31. doi: 10.1248/cpb.50.429.

Authors

Hisashi Matsuda¹, Norihisa Nishida, Masayuki Yoshikawa

Affiliation

¹ Kyoto Pharmaceutical University, Japan.

PMID: 11911215
DOI: 10.1248/cpb.50.429

Abstract

Following the characterization of myrciacitrins I and II and myrciaphenones A and B, three new flavanone glucosides, myrciacitrins III, IV, and V, were isolated from the leaves of Brazilian Myrcia multiflora. The structures of new myrciacitrins were elucidated on the basis of physicochemical and chemical evidence. Myrciacitrins were found to show potent inhibitory activity on aldose reductase.

MeSH terms

Aldehyde Reductase / antagonists & inhibitors*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
Flavonoids / chemistry
Flavonoids / pharmacology
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / pharmacology*
Molecular Structure
Myricaceae / chemistry*
Plant Leaves / chemistry

Substances

Enzyme Inhibitors
Flavonoids
Hypoglycemic Agents
Aldehyde Reductase