Abstract
Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA / chemistry*
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DNA, Single-Stranded / chemistry*
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G-Quadruplexes
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Guanine / chemistry
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Humans
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Inhibitory Concentration 50
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Ligands
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Molecular Structure
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Nucleic Acid Conformation
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Quinolines / chemistry
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Quinolines / metabolism*
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Quinolines / pharmacology*
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Taq Polymerase / antagonists & inhibitors
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Taq Polymerase / chemistry
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Telomerase / antagonists & inhibitors*
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Telomerase / chemistry
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Telomere / enzymology
Substances
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DNA, Single-Stranded
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Ligands
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Quinolines
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Guanine
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DNA
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Taq Polymerase
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Telomerase