Self-consistent quantum approaches are used to study the instabilities of finite nuclear systems. The frequencies of multipole density fluctuations are determined as a function of dilution and temperature for several isotopes. The spinodal region of the phase diagrams is determined, and it appears that instabilities are reduced by finite size effects. The role of surface and volume instabilities is discussed. It is indicated that the important chemical effects associated with mechanical disruption may lead to isospin fractionation.