Abstract
Bioassay-directed fractionation of a Hymeniacidon sp. yielded as nematocidal agents the equilibrating E/Z bromoindole ethyl esters 1 and 2 and corresponding methyl esters 3 and 4. Also isolated for the first time as a natural product was an equilibrating mixture of seco-xanthine formamides, attributed the trivial name hymeniacidin (5). The structure for 5 was assigned on the basis of detailed spectroscopic analysis and total synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antinematodal Agents / chemistry
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Antinematodal Agents / isolation & purification*
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Antinematodal Agents / pharmacology
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Australia
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Bromides / chemistry
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Chromatography, High Pressure Liquid
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera
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Stereoisomerism
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Xanthenes / chemistry
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Xanthenes / isolation & purification*
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Xanthenes / pharmacology
Substances
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Antinematodal Agents
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Bromides
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Indoles
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Xanthenes
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hymeniacidin