Abstract
In this study, some 1-methylene-2,3-diaryl-1,2-dihydropyrazino[1,2-a]benzimidazole and some 1-(2-arylvinyl)-3-arylpyrazino[1,2-a]benzimidazole derivatives were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Anticancer and anti-HIV activities of the compounds were examined, however no anti-HIV activity was seen; highly notable anticancer activity was obtained. It was also observed that the compounds were more potent against leukaemia cell lines.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology*
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Benzimidazoles / therapeutic use
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Cell Division / drug effects
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Cell Line
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Drug Evaluation, Preclinical
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HIV / drug effects
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Humans
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Molecular Structure
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Neoplasms / drug therapy
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Neoplasms / pathology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Benzimidazoles