DNA replication and chromatin

Curr Opin Genet Dev. 2002 Apr;12(2):243-8. doi: 10.1016/s0959-437x(02)00292-7.

Abstract

The study of DNA replication in eukaryotic chromosomes has revealed a multitude of different regulatory levels. Nuclear and chromosomal location as well as chromatin structure may affect the activity of replication origins and their modulation during development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / physiology*
  • DNA Replication / physiology*
  • DNA-Binding Proteins / physiology*
  • Humans
  • Origin Recognition Complex
  • Replication Origin / genetics*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Origin Recognition Complex