Abstract
Significant portions of the eukaryotic genome are heterochromatic, made up largely of repetitious sequences and possessing a distinctive chromatin structure associated with gene silencing. New insights into the form of packaging, the associated histone modifications, and the associated nonhistone chromosomal proteins of heterochromatin have suggested a mechanism for providing an epigenetic mark that allows this distinctive chromatin structure to be maintained following replication and to spread within a given domain.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Chromobox Protein Homolog 5
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Chromosomal Proteins, Non-Histone / physiology
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Drosophila / genetics
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Drosophila / physiology
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Fungal Proteins / physiology
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Gene Silencing / physiology
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Heterochromatin / chemistry
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Heterochromatin / genetics*
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Heterochromatin / physiology
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Histones / physiology
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Saccharomyces cerevisiae Proteins*
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Schizosaccharomyces / genetics
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Schizosaccharomyces / physiology
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Transcription Factors / physiology
Substances
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Chromosomal Proteins, Non-Histone
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Fungal Proteins
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Heterochromatin
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Histones
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SWI6 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Chromobox Protein Homolog 5