Tetrandrine prevents tissue inhibitor of metalloproteinase-1 messenger RNA expression in rat liver fibrosis

Pharmacol Toxicol. 2001 Oct;89(4):214-6. doi: 10.1111/j.0901-9928.2001.890412.x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Alkaloids / therapeutic use*
  • Animals
  • Aspartate Aminotransferases / blood
  • Benzylisoquinolines*
  • Collagen Type I / genetics
  • Collagen Type I / metabolism
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / therapeutic use*
  • Hydroxyproline / metabolism
  • Immunosuppressive Agents / therapeutic use*
  • Liver / drug effects
  • Liver / metabolism
  • Liver Cirrhosis, Experimental / drug therapy*
  • Liver Cirrhosis, Experimental / metabolism*
  • Male
  • RNA, Messenger* / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tissue Inhibitor of Metalloproteinase-1 / genetics
  • Tissue Inhibitor of Metalloproteinase-1 / metabolism*

Substances

  • Alkaloids
  • Benzylisoquinolines
  • Collagen Type I
  • Drugs, Chinese Herbal
  • Immunosuppressive Agents
  • RNA, Messenger
  • Tissue Inhibitor of Metalloproteinase-1
  • tetrandrine
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Hydroxyproline