Abstract
Alginate gel beads were prepared which contained weak acid salts of chitosan (Alg-CS) and water-soluble vitamins (e.g. ascorbic acid (AS)) and the behavior of the beads, uptake of bile acids was investigated in vitro. The Alg-CS beads rapidly took up bile acid and this phenomenon was observed for both hydrogel beads and dried beads. About 120 micromol of taurocholic acid was taken up into Alg-CS (1 g) prepared with orotic acid. Dried Alg-CS is the granule which can be made easily, and keeps the ability of CS salt, and all elements can be taken as a food. Therefore, Alg-CS could serve as a useful dietary agent for the prevention of hyperlipidemia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alginates / pharmacokinetics*
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Bile Acids and Salts / pharmacokinetics
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Biocompatible Materials / pharmacokinetics
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Chemistry, Pharmaceutical
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Chitin / analogs & derivatives
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Chitin / pharmacokinetics*
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Chitosan
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Citric Acid / pharmacokinetics
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Folic Acid / pharmacokinetics
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Glucuronic Acid
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Hexuronic Acids
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Microspheres
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Orotic Acid / pharmacokinetics
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Solubility
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Vitamins / pharmacokinetics*
Substances
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Alginates
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Bile Acids and Salts
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Biocompatible Materials
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Hexuronic Acids
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Vitamins
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Chitin
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Citric Acid
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Orotic Acid
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Glucuronic Acid
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Chitosan
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Folic Acid