Objective: To observe the effect of hypertonic saline solution perfusion on the function of isolated hearts of burned rats.
Methods: The isolated rat heart was taken as the model. The hearts from normal control and burned rats were perfused by improved isotonic (Na(+) 118 mmol/L) and hypertonic Krebs-Henseleit (Na(+) 215 mmol/L) solutions, respectively. The dynamic changes of the cardiac function were monitored during heart perfusion.
Results: The cardiac contractive and diastolic function were transiently inhibited and followed by quick recovery during the perfusion with hypertonic solution in both control and burned rat hearts. But when the hypertonic solution was replaced by isotonic, there appeared significant enhancement of the cardiac contractive and diastolic function. These findings indicated that hypertonic solution exerted more powerful influence on the contractive and diastolic function of burned rat heart.
Conclusion: Hypertonic saline solution could influence the cardiac contractile and diastolic function significantly. And the magnitude of the effects was correlated with the basic cardiac condition.