[Effect of Rhaponticum carthamoides extract on hemorheological properties of blood in rats with arterial hypertension]

Eksp Klin Farmakol. 2001 Nov-Dec;64(6):45-7.
[Article in Russian]

Abstract

The hemorheological activity of a dry extract from Rhaponticum (Leuzea) carthamoides (Willd.) Iljin. was studied in spontaneously hypertensive rats (SHRs). A 14-day treatment of the test rats with a daily dose of 150 mg/kg improved the rheological characteristics, as manifested by a reduced viscosity of the whole blood and plasma, increased spontaneous erythrocyte aggregation and fibrinogen concentration, and increased erythrocyte deformability and electrophoretic mobility against the untreated control level.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antihypertensive Agents / therapeutic use*
  • Cell Aggregation / drug effects
  • Electrophoresis
  • Erythrocyte Deformability / drug effects
  • Fibrinogen / metabolism
  • Hypertension / drug therapy*
  • Male
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Inbred SHR
  • Rats, Wistar
  • Rheology / drug effects*

Substances

  • Antihypertensive Agents
  • Plant Extracts
  • Fibrinogen