Abstract
Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies. Dereplication analysis of the ethyl ether extract was useful for evaluating the components showing significant cytotoxic activity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Survival / drug effects
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Enzyme Induction / drug effects
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Epoxy Compounds / chemistry*
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Epoxy Compounds / isolation & purification
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Epoxy Compounds / pharmacology
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Humans
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Lactones / chemistry*
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Lactones / isolation & purification
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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NAD(P)H Dehydrogenase (Quinone) / biosynthesis
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NAD(P)H Dehydrogenase (Quinone) / drug effects
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Phytosterols / chemistry*
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Phytosterols / isolation & purification
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Phytosterols / pharmacology
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Solanaceae / chemistry*
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Tumor Cells, Cultured / drug effects*
Substances
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Antineoplastic Agents
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Epoxy Compounds
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Lactones
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Phytosterols
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NAD(P)H Dehydrogenase (Quinone)