Anti-inflammatory compounds from the bitter mushroom, Sarcodon scabrosus

Biosci Biotechnol Biochem. 2002 Jan;66(1):179-84. doi: 10.1271/bbb.66.179.

Abstract

A bioassay-guided purification procedure from the methanol extract of Sarcodon scabrosus led to the isolation of several anti-inflammatory compounds: sarcodonin A (1) and G (2), and related compounds (3, 4 and 5). We named these related compounds neosarcodonin A (3), B (4) and C (5) and elucidated their structures on the basis of spectral data. Topical application of each of these compounds to mouse ears suppressed TPA-induced inflammation. Neosarcodonin C (5) exhibited the highest activity and inhibited the TPA-induced edema on mouse ears by up to 87% with a 200-microg application.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Mice
  • Molecular Structure

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diterpenes
  • sarcodonin G