Objective: To select an optimal vaccination approach and provide basis for decision-making on the control of hepatitis B infection in PLA.
Methods: Decision trees were constructed. The yearly new infection rate in susceptible cohort, using a catalytic model, was estimated. Disability-adjusted life year (DALY) was used to assess the effectiveness. Incremental cost-effectiveness ratio (CER) was then calculated.
Results: Compared with no vaccination, DALY of immediate vaccination and vaccination after screening were 61.89 and 57.18 with CER 392.70 and 251.90 respectively. After weighting with actual age construction of PLA population, the CERs of vaccination after screening and immediate vaccination were 251.90 and 392.70 respectively.
Conclusion: The results indicated that screening followed by vaccination was superior to immediate vaccination approach. The younger the vaccination was carried out, the more cost-effective was shown by vaccination.