Amphidinolide W, a new 12-membered macrolide from dinoflagellate Amphidinium sp

J Org Chem. 2002 Feb 8;67(3):1020-3. doi: 10.1021/jo016089o.

Abstract

A new cytotoxic 12-membered macrolide, amphidinolide W (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data including (13)C-(13)C INADEQUATE correlations for its (13)C-enriched sample. The absolute stereochemistry of 1 was assigned by combination of J-based configuration analysis and modified Mosher method. Amphidinolide W (1) is the first macrolide without an exomethylene unit among all amphidinolides obtained so far.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dinoflagellida / chemistry*
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry / methods
  • Molecular Structure

Substances

  • Macrolides
  • amphidinolide W