Stabilization of pharmaceuticals to oxidative degradation

Pharm Dev Technol. 2002 Jan;7(1):1-32. doi: 10.1081/pdt-120002237.

Abstract

A guide for stabilization of pharmaceuticals to oxidation is presented. Literature is presented with an attempt to be a ready source for data and recommendations for formulators. Liquid and solid dosage forms are discussed with options including formulation changes, additives, and packaging documented. In particular, selection of and methods for use of antioxidants are discussed including recommended levels.

Publication types

  • Review

MeSH terms

  • Antioxidants / pharmacology
  • Catalysis
  • Chemistry, Pharmaceutical
  • DNA / chemistry
  • Drug Stability*
  • Hydrogen-Ion Concentration
  • Oxidation-Reduction
  • Proteins / chemistry
  • Solubility
  • Sterilization

Substances

  • Antioxidants
  • Proteins
  • DNA