Abstract
Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.
MeSH terms
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Antibiotics, Antitubercular / metabolism*
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Antibiotics, Antitubercular / pharmacology
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Biofilms / drug effects*
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Cell Wall / drug effects
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Cell Wall / ultrastructure
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Kinetics
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Microscopy, Electron
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Microscopy, Electron, Scanning
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Rifampin / metabolism*
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Rifampin / pharmacology
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / metabolism*
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Staphylococcus epidermidis / ultrastructure
Substances
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Antibiotics, Antitubercular
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Rifampin