Abstract
Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Carrier Proteins / metabolism
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Chromosomes, Human, Pair 11
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Consensus Sequence
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Cytoskeletal Proteins
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Herpesvirus 4, Human / physiology
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Humans
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Interferon Regulatory Factor-7
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Intracellular Signaling Peptides and Proteins
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LIM Domain Proteins
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Phosphorylation
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Protein Structure, Tertiary
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Transcription Factors / chemistry*
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Transcription Factors / genetics
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Transcription Factors / physiology*
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Transcriptional Activation
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Virus Latency
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Cytoskeletal Proteins
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DNA-Binding Proteins
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IRF7 protein, human
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Interferon Regulatory Factor-7
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Intracellular Signaling Peptides and Proteins
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LIM Domain Proteins
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PDLIM7 protein, human
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Transcription Factors