Abstract
Benzylidene rhodanines are novel inhibitors of UDP N-acetylmuramate/L-alanine ligase. They showed selective whole-cell activity against the Gram-positive MRSA but not against the Gram-negative Escherichia coli. Their cytotoxic effect on mammalian CHO cells was also evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Benzylidene Compounds / chemical synthesis
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Benzylidene Compounds / pharmacology
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CHO Cells / drug effects
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Cell Survival / drug effects
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Cricetinae
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Peptide Synthases / antagonists & inhibitors*
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Rhodanine / chemical synthesis
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Rhodanine / pharmacology
Substances
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Anti-Bacterial Agents
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Benzylidene Compounds
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Enzyme Inhibitors
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Rhodanine
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Peptide Synthases
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UDP-N-acetylmuramoyl-alanine synthetase