Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligase

Bioorg Med Chem Lett. 2002 Feb 25;12(4):697-9. doi: 10.1016/s0960-894x(01)00832-0.

Abstract

Benzylidene rhodanines are novel inhibitors of UDP N-acetylmuramate/L-alanine ligase. They showed selective whole-cell activity against the Gram-positive MRSA but not against the Gram-negative Escherichia coli. Their cytotoxic effect on mammalian CHO cells was also evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Benzylidene Compounds / chemical synthesis
  • Benzylidene Compounds / pharmacology
  • CHO Cells / drug effects
  • Cell Survival / drug effects
  • Cricetinae
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Peptide Synthases / antagonists & inhibitors*
  • Rhodanine / chemical synthesis
  • Rhodanine / pharmacology

Substances

  • Anti-Bacterial Agents
  • Benzylidene Compounds
  • Enzyme Inhibitors
  • Rhodanine
  • Peptide Synthases
  • UDP-N-acetylmuramoyl-alanine synthetase